An saita Highschool of the Dead a yau a Japan, farawa kamar yadda aka buga duniyar tamu da mummunar cutar da ke juya mutane zuwa zombies, waɗanda aka ambata da kyau daga manyan haruffa kamar “Su” (?? Yatsura?).
Labarin ya biyo bayan ɗaliban makarantar sakandare (da ma kwalejin nas) yayin da suka jimre ta amfani da wani mummunan bala'in da ya faru a duk duniya wanda ake kira "Cutar Cutar". Hakanan dole ne su tunkari ƙarin haɗarin faduwar rayuwa, a cikin irin waɗanda suka tsira masu haɗari, da kuma yiwuwar lalacewar ƙa'idodin ɗabi'unsu na musamman yayin da 'yan wasan ke ƙoƙarin tsira da rayuwar aljan. Farawa daga HS, ɗaliban sun shiga cikin gari a inda zasu shawo kan ɗalibansa da malami mai ƙazanta. Suna samun kare kazalika karamar yarinya, kuma suna tantance wadanda suka rayu a gidajensu. Bayan haka, daga ƙarshe sun koma hanyar makarantar firamare wacce ake zargin yanki ne mai tsaro, ta hanyar ofishin 'yan sanda, kuma ta ƙarshe a cibiyar kasuwanci.
